Table of Antipsychotics

Drug Receptor Affinity   Main Side Effects
  D1 D2 mACH 5HT2   EPS Sed. Hypo.  Other
Typical
Chlorpromazine ++ +++  ++ ++   ++ ++ ++

Increased prolactin (gynaecomastia)

Hypothermia 

Anticholinergic effects

Hypersensitivity reactions

Obstructive jaundice
Thioridazine + ++ ++ ++   + ++ ++ As chlorpromazine, but does not cause jaundice
Haloperidol + +++ + / - +   +++   ++

As chlorpromazine, but does not cause jaundice

Fewer anticholinergic side effects
Flupenthixol ++ +++ - +++   ++ + +

Increased prolactin (gynaechomastia)

Restlessness
 
Atypical
Sulpiride   +++       + +    Increased prolactin (gynaecomastia)
Clozapine ++ ++ ++ +++     ++ +

Risk of agranulocytosis

Seizures

Sedation

Salivation

Anticholinergic side effects

Weight gain
Risperidone   ++ ++ +++    + ++ +

Weight gain

EPS at high doses

Hypotension
Sertindole   ++   +++   + +  ++

Ventricular arrhythmias

Weight gain

Nasal congestion
Quetiapine   + + +   +  ++ ++

Tachycardia

Agitation

Dry mouth

Weight gain

Table reproduced from:  Rang, H. P., Dale, M. M., Ritter, J. M., & Moore, P. K. (2003). Pharmacology (5th Edition ed.). London: Churchill Livingstone, Elsevier Limited.

Table Legend

 

D1 = Dopamine Receptor 1

D2 = Dopamine Receptor 2

mACH = Muscarinic Acetylcholine

5-HT2 = Serotonin Receptor 2

EPS = Extra-pyramidal Side Effects

Sed. = Sedation

Hypo. = Hypotension